Staff at the Department for Business, Innovation and Skills (BIS) have lost 100 devices - both BlackBerrys and laptops - in the past three years.
A freedom of information request by security firm Veracode found that the losses have occurred repeatedly in recent years, with 24 BlackBerry's lost in 2010/11, 35 in 2011/12 and 24 in 2012/2013.
Senior security researcher at Veracode, Tyler Shields, said the losses underlined the risks associated with using mobile devices and was obviously keen to the tout security methods that can be used to mitigate against device loss.
"It's critical for the government to not only secure these devices with mobile location and remote lock and wipe technology, but also secure the apps that reside on them," he said.
"A phone or tablet does not have to go lost or stolen to be at risk, and ensuring the security of mobile applications is equally critical to protecting against an ever increasing threat profile to governments and businesses alike."
BIS said it admitted the losses were "unfortunate" but defended the numbers as low compared to the number of devices issued and that it had taken all the necessary action to mitigate against losses before they happen.
"All departmental laptops and BlackBerry devices are encrypted and password protected while strict IT security rules must be adhered to by all staff in their proper use of IT and their responsibilities," a spokesperson told V3.
"In the event of loss or theft, the Department takes prompt action to remotely deactivate any computing device to ensure the risk of data compromise is minimised and to guard against unauthorised use or intrusion."
In other government IT related news the Cabinet Office confirmed on Thursday that it was doing away with a dedicated chief information officer role at the top of government as part of a wider overhaul.
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