The 2004 MyDoom infection caused the most financial damage of all malicious software deployed in the past decade, according to a new report from McAfee.
The security vendor's report on Ten Years of Cybercrime (PDF) estimates that costs from lost productivity and commerce from MyDoom's huge spam campaigns reached $38bn (£24bn). At its peak, MyDoom-related spam slowed global internet traffic by 10 per cent.
The second most destructive piece of malware came in 2000 when the I Love You outbreak rang up estimated removal and lost productivity costs of $15bn (£9.4bn).
Third on the list was the 2009 Conficker outbreak, which cost an estimated $9.1bn (£5.7bn) in damages and generated headlines when researchers discovered that certain versions of the malware contained time-sensitive instructions.
McAfee said that MyDoom and I Love You reflected the attitudes of malware writers in the early part of the decade, when malware was often designed to garner attention and cyber criminals were only beginning to monetise their products.
Later samples, such as Conficker and the ZeuS botnet tool, emerged towards the end of the decade and were designed to operate with little visibility, giving the malware writer control over the victim's machine for as long as possible.
The later half of the decade also saw a rise in fake anti-virus tools, or 'scareware', which pose as legitimate security programs. McAfee identified such operations as the most common online scam during the decade.
Other common scams included phishing operations, online dating cons and 'advance fee' fraud operations that ask recipients to send money to facilitate a larger cash transaction.
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