The cargo will form the basis of Nasa's plans to have a permanent crew of six in orbit to increase the amount of useful scientific data that the Space Station can create.
This mission takes up new sleeping quarters, vital recycling facilities, the first refrigerator and an extra toilet, which will be useful considering a series of malfunctions earlier this year.
"When the fourth Space Shuttle mission of the year is complete, the ISS will have all of the key systems needed to turn what is now a three-bedroom, one-bathroom home for three, into a five-bedroom, two-bath residence for six," said Nasa.
The 15-day mission will also see essential maintenance on the solar arrays that power the station, and allow one of the crew members to return home.
IBM and Technical University of Munich team demonstrate how Shor's algorithm, which can't be cracked by conventional computers, can be solved quickly with quantum computing
Hubble Space Telescope finds superflares from young red dwarfs could strip away planetary atmosphere
Younger stars are 100 to 1,000 times more energetic than when they're older
Two of the big four supermarkets will use the system to control sales of restricted products
PUBG news and updates: November's Update #23 to bring new Skorpion pistol and changes to blue zone visibility
Genuinely useful side-arm coming to PUBG in Update #23