The iconic Yamaha DC6A Pro digital acoustic 6ft 11in grand piano, played by the star at a variety of special events surrounding his hit shows in Las Vegas, will be sold off to support the Elton John Aids Foundation.
The famous grand piano, nicknamed 'Fiona', was on display in the Colosseum Lobby at Caesars Palace in Las Vegas.
Sir Elton will play the piano for the final time at the 14th Annual Elton John Aids Foundation Viewing Dinner and After-Party to celebrate the Academy Awards on 5 March in Los Angeles.
The singer will then autograph the piano in preparation for delivery to the lucky auction winner.
"The charity auction of this one-of-a-kind piano on eBay offers a unique opportunity for a fan or collector to own a major piece of music history while raising funds to support the critical work of prevention, education and treatment of Aids," said Scott Campbell, director of the Elton John Aids Foundation.
The charity auction will begin on Monday 27 February and conclude on Thursday 9 March.
Geoengineering on the sea floor near glaciers would form a new ice shelf to prevent melting
Alterations in capillary blood flow can be caused by body position change
Curiosity rover is in 'normal mode' but not transmitting scientific data back to base
NatWest outage comes a day after Barclays' IT systems shut out customers and staff