Nasa has a long-standing tradition of waking the Space Station inhabitants with music, which it believes helps to reduce stress levels.
On 12 November McCartney will beam up a live track from his new album English Tea as well as The Beatles track Good Day Sunshine.
This is something of a reprise for Nasa, since Good Day Sunshine was played for the crew of the space shuttle Discovery on their last flight in August.
"I was extremely proud to find out one of my songs was played for the crew of Discovery this summer," said McCartney. "In our concert we hope to repay the favour."
The music will come from one of the last gigs in McCartney's US tour in Anaheim, California.
Researchers claim first in race to manufacture a component able to host Majorana particles
Japanese researchers develop a flexible screen worn on the skin that they claim can monitor patients' heart rate and other vitals
ZenFone 5 Pro appears to boast a Snapdragon 845 SOC, an Adreno 630 GPU and 6GB of RAM
Pilot project will serve 300 homes to start with