The live programme will be streamed from Leicester Square to countries including Japan, Australia, Mexico, Argentina and the US as well as the UK.
An edited version of the coverage will be available to view on AOL's dedicated Spider-Man website for around three months.
Dan Patton, head of digital entertainment at AOL, said: "It is AOL's intention to provide our users with unique and quality content, and our involvement with Spider-Man 3 really highlights that."
Spider-Man 3 opens in UK cinemas on 4 May.
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