TrueCrypt 6.2a is free encryption technology that you can use to secure your drive and prevent unauthorised users from gaining access to the contents. You can create an encrypted volume, if you desire, and simply read/write to this volume as if it was a standard partition. As TrueCrypt is a cross-platform tool, if you decided to turn your portable USB key in to an encrypted drive, you could simply move this to/from your PC and Mac and use it with few compatibility issues (irrespective of the NTFS read/write issues).
TrueCrypt for Windows and for Mac links.
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